Członkowski A, Członkowska A
Acta Neurol Scand. 1984 May;69(5):298-301. doi: 10.1111/j.1600-0404.1984.tb07816.x.
Biochemical studies of CSF from patients with Wilson's disease (WD) have increased that alterations in the state of dopaminergic and serotoninergic systems are similar to those manifested in Parkinson's disease. Recently, the density of dopaminergic receptors on lymphocytes has been found to be diminished in Parkinson's disease. In the present study, 3H-spiroperidol binding was evaluated in lymphocytes acquired from 12 patients suffering from WD, as compared to blood donors. A significant decrease in the number of binding sites (Bmax) was observed in the lymphocytes of the WD patients. There was no clear relationship between clinical status, age and duration of the disease and the alterations in receptor density. The mechanism underlying the decrease in lymphocyte 3H-spiroperidol binding sites in WD demands clarification.
对威尔逊病（WD）患者脑脊液的生化研究表明，多巴胺能和5-羟色胺能系统状态的改变与帕金森病中表现出的改变相似。最近发现，帕金森病患者淋巴细胞上多巴胺能受体的密度降低。在本研究中，与献血者相比，对12例WD患者的淋巴细胞进行了³H-螺哌啶醇结合评估。WD患者的淋巴细胞中观察到结合位点数量（Bmax）显著减少。疾病的临床状态、年龄和病程与受体密度改变之间没有明确关系。WD患者淋巴细胞³H-螺哌啶醇结合位点减少的潜在机制有待阐明。
