Rotstein E, Mishra R K, Singal D P, Barone D
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):729-32. doi: 10.1016/0278-5846(83)90054-4.
Binding of 3H-spiroperidol was determined in ten (10) unmedicated recently admitted and four (4) drug holiday schizophrenic patients to determine whether it could serve as a peripheral marker of central dopaminergic hyperactivity. Preliminary results indicate significantly increased binding but there is considerable intersubject variability. Displacement studies, the lack of stereospecificity and the necessity of having an intact lymphocyte do not indicate that this is binding to a dopamine receptor but rather an uptake phenomenon.
对10名近期入院且未接受药物治疗的患者以及4名处于药物假期的精神分裂症患者进行了³H-螺哌啶醇结合试验，以确定其是否可作为中枢多巴胺能亢进的外周标志物。初步结果显示结合显著增加，但个体间存在相当大的差异。置换研究、缺乏立体特异性以及完整淋巴细胞的必要性表明，这并非与多巴胺受体的结合，而是一种摄取现象。
