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兔关节腔内注射钇90。不同放射性胶体在兔和人体中的行为比较。

Intra-articular yttrium 90 in rabbits. Comparison of behaviour of various radiocolloids in rabbits and in man.

作者信息

Gumpel J M

出版信息

Ann Rheum Dis. 1978 Apr;37(2):195-7. doi: 10.1136/ard.37.2.195.

Abstract

Comparative studies of the retention of various yttrium 90 radiocolloids and of noncolloidal yttrium 90 chloride were performed in rabbits with arthritis induced in one knee. Two colloids, the citrate and resin forms, showed a statistically significant difference in retention between inflamed and normal knees, isotope being retained better in the normal knee. Marked differences were found in the handling of the various yttrium preparations in rabbits compared with previously reported results in man. These differences suggest that the rabbit with induced arthritis is not a suitable model in which to test retention of different radiocolloids before use in man.

摘要

在单膝诱发关节炎的兔子身上,对各种钇90放射性胶体和非胶体氯化钇90的滞留情况进行了对比研究。两种胶体,即柠檬酸盐和树脂形式,在发炎膝盖和正常膝盖之间的滞留情况存在统计学上的显著差异,同位素在正常膝盖中的滞留效果更好。与先前报道的人体研究结果相比,在兔子身上处理各种钇制剂时发现了显著差异。这些差异表明,诱发关节炎的兔子并非一个适合在人体应用前测试不同放射性胶体滞留情况的模型。

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