Bielefeldt Ohmann H
Acta Vet Scand. 1984;25(1):36-49. doi: 10.1186/BF03547277.
An epizootic characterized by birth of calves severly ataxic and blind were encountered in 3 herds 7–8 months after outbreaks of bovine virus diarrhoea. Serological and virological investigations indicated introduction of bovine viral diarrhoea virus (BVDV) into previously virus-free herds, followed by transplacental virus infection of the fetuses of cows in the first trimester. Clinical, pathological, serological, and microbiological examinations were performed on 10 calves. Pathological findings included microcephaly and cerebellar hypoplasia, ocular malformations, and thymic hypoplasia. BVDV was isolated from tissue and blood of 7 calves, and 4 calves, 1 of which had not received colostrum, had virus-specific neutralizing antibodies. This is the first report on natural occurrence of congenital bovine infection with BVDV among Danish cattle herds resulting in abortion and birth of calves with severe debilitating congenital anomalies. It draws attention to the importance of this virus for bovines of all age groups.
在牛病毒性腹泻暴发7至8个月后，3个牛群中出现了一种以出生的犊牛严重共济失调和失明为特征的 epizootic。血清学和病毒学调查表明，牛病毒性腹泻病毒（BVDV）传入了先前无病毒的牛群，随后在妊娠早期经胎盘感染了母牛的胎儿。对10头犊牛进行了临床、病理、血清学和微生物学检查。病理检查结果包括小头畸形和小脑发育不全、眼部畸形以及胸腺发育不全。从7头犊牛的组织和血液中分离出了BVDV，4头犊牛具有病毒特异性中和抗体，其中1头未摄入初乳。这是丹麦牛群中首次关于BVDV先天性牛感染自然发生的报告，该感染导致流产以及出生患有严重先天性衰弱异常的犊牛。它提醒人们注意这种病毒对所有年龄组牛的重要性。
