Davis M J, Hockings B E, el Dessouky M A, Hajar H A, Taylor R R
Am J Cardiol. 1984 Aug 1;54(3):282-5. doi: 10.1016/0002-9149(84)90183-8.
With use of 24-hour ambulatory electrocardiographic monitoring, the effect of 1 hour of cigarette smoking on cardiac rhythm in 73 patients with coronary heart disease was studied. Fifteen subjects had no arrhythmia; 37 subjects had fewer than 2 atrial or ventricular premature complexes (APCs or VPCs)/hour, with APCs possibly related to smoking in 2 and VPCs related to smoking in 1. Nineteen subjects had more than 2 VPCs/hour (range 4 to 368) and had 16 +/- 29 VPCs/hour (+/- standard deviation) less during than before smoking (p less than 0.05), associated with an increase in heart rate of 4.6 +/- 6.8 beats/min (p less than 0.01). In none of the 9 subjects with unifocal VPCs did multiform beats develop during or after smoking, whereas 3 of 10 subjects with multiform VPCs had only unifocal beats during and immediately after smoking. In 1 of these 19 subjects, frequent APCs developed during smoking. One other subject had frequent APCs unaffected by smoking and another had sinoatrial block, which disappeared during smoking on 1 of 3 monitorings. In conclusion, no sustained or high-grade ventricular arrhythmia was provoked by smoking; although APCs may have been related to smoking in a few persons, the frequency and complexity of VPCs tended to be reduced in these subjects with coronary artery disease.
通过使用24小时动态心电图监测，研究了73例冠心病患者吸烟1小时对心律的影响。15名受试者无心律失常；37名受试者每小时房性或室性早搏（APCs或VPCs）少于2次，其中2例APCs可能与吸烟有关，1例VPCs与吸烟有关。19名受试者每小时VPCs超过2次（范围4至368次），吸烟期间每小时VPCs比吸烟前减少16±29次（±标准差）（p<0.05），同时心率增加4.6±6.8次/分钟（p<0.01）。9名单形性VPCs受试者中，无一例在吸烟期间或吸烟后出现多形性早搏，而10名多形性VPCs受试者中有3名在吸烟期间及吸烟后立即仅出现单形性早搏。在这19名受试者中，有1名在吸烟期间出现频繁的APCs。另一名受试者有不受吸烟影响的频繁APCs，还有一名受试者有窦房阻滞，在3次监测中的1次监测时吸烟期间消失。总之，吸烟未诱发持续性或高级别室性心律失常；虽然少数人的APCs可能与吸烟有关，但这些冠心病受试者中VPCs的频率和复杂性趋于降低。
