McCarthy D O, Kluger M J, Vander A J
Am J Clin Nutr. 1984 Aug;40(2):310-6. doi: 10.1093/ajcn/40.2.310.
In order to test the hypothesis that fever, and not some other aspect of the acute phase response, decreases food intake after administration of endotoxin, food intake of rats was studied under conditions of 1) fever, 2) antipyresis, and 3) endotoxin tolerance. Injection of endotoxin resulted in a significant elevation in rectal temperature and a significant reduction in food intake. Administration of the antipyretic drug sodium salicylate to endotoxin-injected animals lowered rectal temperatures to control levels, but food intake was still suppressed. When rats were made tolerant to endotoxin by repeated injections, an attenuated fever was observed, and food intake was not significantly different from that of control animals. We conclude that the effects of endotoxin on body temperature can be dissociated from its effects on food intake. We speculate that the failure of endotoxin to suppress food intake in endotoxin-tolerant rats may be due to a decreased production of endogenous pyrogen.
为了验证内毒素给药后是发热而非急性期反应的其他方面导致食物摄入量减少这一假说，我们在以下三种条件下研究了大鼠的食物摄入量：1）发热；2）解热；3）内毒素耐受。注射内毒素导致直肠温度显著升高，食物摄入量显著减少。给注射内毒素的动物服用解热药物水杨酸钠可使直肠温度降至对照水平，但食物摄入量仍受到抑制。当大鼠通过反复注射对内毒素产生耐受时，观察到发热减弱，且食物摄入量与对照动物无显著差异。我们得出结论，内毒素对体温的影响可与其对食物摄入量的影响相分离。我们推测，内毒素耐受大鼠中内毒素未能抑制食物摄入可能是由于内源性热原的产生减少。
