Nava F, Calapai G, Facciolá G, Cuzzocrea S, Marciano M C, De Sarro A, Caputi A P
Institute of Pharmacology, School of Medicine, University of Messina, Italy.
Int J Immunopharmacol. 1997 Jan;19(1):31-8. doi: 10.1016/s0192-0561(97)00006-4.
Intracerebroventricular (i.c.v.) interleukin-10 (25, 50, and 100 ng/rat) effects on water intake, exploratory behaviour, and rectal temperature were evaluated in rats treated intraperitoneally (i.p.) with lipopolysaccharide (0.32, 0.64, and 0.96 mg/kg). Endotoxin administration induced fever and inhibition of thirst in water-deprived rats, and a decrease in lococomotory activity in normohydrated and water-deprived animals. Our data show that interleukin-10 during lipopolysaccharide administration controlled fever, increases exploratory behaviour, but did not reverse lipopolysaccharide inhibition of thirst. These effects suggest that fever, depression in locomotory activity but not inhibition of thirst, induced by endotoxin are influenced by interleukin-10 levels.
