Crandall D L, Goldstein B M, Gabel R A, Cervoni P
Am J Physiol. 1984 Aug;247(2 Pt 2):R266-71. doi: 10.1152/ajpregu.1984.247.2.R266.
The effect of defined increments of weight loss on hemodynamics has been investigated in conscious, unrestrained, spontaneously obese rats. Obese rats were subjected to a calorically restricted diet and were used for experimentation on achieving a 10, 20, or 30% reduction in body weight. After monitoring resting blood pressure and heart rate, radioactive microspheres were infused for determination of blood flow distribution. Of 10 organs sample, only heart, liver, kidneys, and 2 adipose tissue depots exhibited significant decreases in weight associated with body weight reduction. Mean arterial blood pressure remained unchanged, while stroke volume, left ventricular work, and cardiac output decreased significantly. Blood flow decreased to kidneys, testes, and adipose tissue through a 30% reduction in body weight, but the fractional distribution of cardiac output decreased only to adipose tissue. Therefore the large decreases in renal and adipose tissue blood flow during weight reduction may contribute to the associated decrease in cardiac output. Of those vascular beds examined, however, both absolute and relative blood flow decreased only to adipose tissue, thus denoting the influence of fat mass on hemodynamics during obesity.
在清醒、无束缚、自发性肥胖的大鼠中，研究了特定体重减轻增量对血流动力学的影响。肥胖大鼠接受热量限制饮食，并用于实现体重减轻10%、20%或30%的实验。在监测静息血压和心率后，注入放射性微球以测定血流分布。在10个器官样本中，只有心脏、肝脏、肾脏和2个脂肪组织库的重量随着体重减轻而显著下降。平均动脉血压保持不变，而每搏输出量、左心室作功和心输出量显著下降。体重减轻30%时，肾脏、睾丸和脂肪组织的血流量减少，但心输出量的分数分布仅在脂肪组织中减少。因此，体重减轻期间肾脏和脂肪组织血流量的大幅减少可能导致心输出量相应下降。然而，在所检查的那些血管床中，绝对和相对血流量仅在脂肪组织中减少，从而表明肥胖期间脂肪量对血流动力学的影响。
