Crandall D L, Goldstein B M, Lizzo F H, Gabel R A, Cervoni P
Am J Physiol. 1986 Aug;251(2 Pt 2):R314-9. doi: 10.1152/ajpregu.1986.251.2.R314.
Direct quantitation of blood flow with radioactive microspheres in conscious spontaneously obese rats indicated that the development of obesity was associated with an elevated cardiac output and stroke volume, a normotensive blood pressure, and a reduced total peripheral resistance when directly comparing obese rats with their lean counterparts. Obesity was also associated with increased blood flow and decreased regional vascular resistance in a variety of vascular beds, whereas cardiac index and total peripheral resistance per unit of body weight were similar between groups. When corrected for tissue weight, unique alterations in flow and resistance were observed in the adipose tissue. When expressed as resistance per organ, the greatest relative alterations in vascular resistance with the development of obesity also occurred in the adipose tissue. Furthermore, localized adipose tissue expansion through cellular hypertrophy was consistently associated with a different pattern of blood flow and vascular resistance than adipose tissue that expanded through both cellular hypertrophy and hyperplasia, implying an association between depot cellularity and its hemodynamic profile.
在清醒的自发性肥胖大鼠中，用放射性微球直接定量血流量表明，与瘦鼠相比，肥胖的发展与心输出量和每搏输出量升高、血压正常以及总外周阻力降低有关。肥胖还与多种血管床的血流量增加和局部血管阻力降低有关，而两组之间的心脏指数和单位体重总外周阻力相似。当校正组织重量时，在脂肪组织中观察到血流量和阻力的独特变化。当以每个器官的阻力表示时，肥胖发展过程中血管阻力的最大相对变化也发生在脂肪组织中。此外，通过细胞肥大导致的局部脂肪组织扩张与通过细胞肥大和增生共同导致的脂肪组织扩张相比，始终具有不同的血流和血管阻力模式，这意味着脂肪储存细胞构成与其血流动力学特征之间存在关联。
