Kintzer J S, Rosenow E C, Kyle R A
Arch Intern Med. 1978 May;138(5):727-30.
Review of the records of 958 patients with multiple myeloma disclosed thoracic skeletal or pleuropulmonary abnormalities or both in 443 patients (46%). The abnormalities were an initial finding on 25% of the chest roentgenograms. The most common finding, exclusive of plasmacytomas, was thoracic skeletal abnormality in 28% (the initial finding in 15%)--osteolytic lesions being the most frequent abnormality. Localized or diffuse pulmonary infiltrates, most often caused by infections, were present in 10%. Four patients had a diffuse infiltrate thought to be caused by a plasma cell infiltrate (proven in one). In 113 patients, plasmacytomas were seen (intramedullary 102, extramedullary 11)--as an initial finding in 8%. Fifty-eight patients (6%) had pleural effusions. Eight patients with pleural effusion caused by myeloma are added to the eight cases reported in the literature.
对958例多发性骨髓瘤患者的记录进行回顾发现，443例患者（46%）存在胸部骨骼或胸膜肺部异常或两者皆有。这些异常在25%的胸部X线片上是最初发现的。最常见的发现（不包括浆细胞瘤）是28%的患者存在胸部骨骼异常（15%为最初发现），溶骨性病变是最常见的异常。10%的患者存在局部或弥漫性肺部浸润，最常见的原因是感染。4例患者有被认为由浆细胞浸润引起的弥漫性浸润（1例得到证实）。113例患者可见浆细胞瘤（髓内102例，髓外11例），8%为最初发现。58例患者（6%）有胸腔积液。8例由骨髓瘤引起胸腔积液的患者被补充到文献报道的8例病例中。
