Burch R E, Sackin D A, Ursick J A, Jetton M M, Sullivan J F
Arch Intern Med. 1978 May;138(5):743-6.
The sensory modalities of taste and smell were evaluated in eight patients with cirrhosis that was proved by biopsy specimens and in 13 control subjects. Additionally, the following serum levels were determined in these same subjects: zinc, copper, magnesium, calcium, manganese, and selenium. Fourteen concentrations each of sucrose, sodium chloride, urea, and hydrochloric acid were used to evaluate taste acuity. Smell was evaluated with 11 concentrations each of nitrobenzene, thiophene, and pyridine. These studies show that decreased acuity of taste and smell occurred in conjunction with cirrhosis in the patients who were tested. There were no trace element abnormalities that consistently correlated with decreased acuity in perception of the individual test substances.
通过活检标本证实患有肝硬化的8例患者和13名对照受试者接受了味觉和嗅觉的感觉功能评估。此外，还测定了这些受试者相同的以下血清水平：锌、铜、镁、钙、锰和硒。分别使用14种浓度的蔗糖、氯化钠、尿素和盐酸来评估味觉敏锐度。使用11种浓度的硝基苯、噻吩和吡啶来评估嗅觉。这些研究表明，接受测试的肝硬化患者出现味觉和嗅觉敏锐度下降。在个体测试物质的感知敏锐度下降方面，没有发现始终相关的微量元素异常。
