Zarski J P, Arnaud J, Dumolard L, Favier A, Rachail M
Gastroenterol Clin Biol. 1985 Oct;9(10):664-9.
The authors studied the influence of alcohol intake and liver disease in the disturbances of trace elements detected in patients with alcoholic cirrhosis. A determination of zinc, copper and manganese was carried out in the serum, the 24 h urine and a liver sample in 15 patients with alcoholic cirrhosis, 11 chronic alcoholics and 17 control subjects. In the serum of cirrhotic patients, zinc was significantly decreased, copper and manganese significantly increased. In the liver, zinc was decreased and copper increased, but the difference did not read significantly. The elimination of zinc in urine was increased and that of manganese decreased. In the chronic alcoholic patients only the serum zinc was decreased. Chronic alcoholism seemed to be therefore one of the factors responsible for low serum zinc in patients with alcoholic liver disease.
作者研究了酒精摄入量和肝脏疾病对酒精性肝硬化患者体内微量元素紊乱的影响。对15例酒精性肝硬化患者、11例慢性酒精中毒者和17例对照者的血清、24小时尿液及肝脏样本进行了锌、铜和锰含量的测定。在肝硬化患者的血清中，锌显著降低，铜和锰显著升高。在肝脏中，锌降低而铜升高，但差异无统计学意义。尿中锌的排泄增加而锰的排泄减少。在慢性酒精中毒患者中，仅血清锌降低。因此，慢性酒精中毒似乎是导致酒精性肝病患者血清锌含量低的因素之一。
