Hansbrough J F, Zapata-Sirvent R L, Carroll W J, Johnson R, Saunders C E, Barton C A
Am J Surg. 1984 Aug;148(2):266-9. doi: 10.1016/0002-9610(84)90235-6.
We studied the effects of intravenous alcohol infusions on 22 alcoholic burn patients admitted to our burn center. The relationship of infusion rates to blood alcohol levels was studied over a 3 to 8 day period of administration, and daily blood test results in liver function were followed. No patients had signs of withdrawal either during the infusion period or after the discontinuation of alcohol therapy. Our data suggest that the intravenous infusion of ethanol at rates of 0.02 to 0.06 g/kg per hour provides low but measurable blood alcohol levels (2 to 8 mg/100 ml), avoids sedation and toxic effects, and prevents the appearance of withdrawal symptoms in severely alcoholic burn patients.
我们研究了静脉输注酒精对入住我们烧伤中心的22例酒精性烧伤患者的影响。在3至8天的给药期间,研究了输注速率与血液酒精水平之间的关系,并跟踪了每日肝功能血液检测结果。在输注期间或停止酒精治疗后,没有患者出现戒断症状。我们的数据表明,以每小时0.02至0.06克/千克的速率静脉输注乙醇可提供低但可测量的血液酒精水平(2至8毫克/100毫升),避免镇静和毒性作用,并防止重度酒精性烧伤患者出现戒断症状。