St Haxholdt O, Krintel J J, Johansson G
Anaesthesia. 1984 Mar;39(3):240-5. doi: 10.1111/j.1365-2044.1984.tb07234.x.
The influence of pre-operative alcohol infusion on the requirement for analgesic supplementation with fentanyl in chronic alcoholic patients was studied. The chronic alcoholic was defined as a person having a regular daily alcohol consumption of over 70 g pure alcohol for at least 3 years. The mean annual consumption in the patients studied was 52 litres pure alcohol. A positive correlation between requirement for fentanyl and alcohol consumption was found. The amount of fentanyl required to achieve satisfactory analgesia (the 'saturation dose') was significantly higher (61%) in alcoholic than in non-alcoholic patients. Once stable anaesthesia was achieved the maintenance dose was the same in alcoholic and non-alcoholic patients. Pre-operative infusion of alcohol significantly reduced the amount of fentanyl required to achieve anaesthesia in both alcoholic and non-alcoholic patients (by 25% and 29% respectively). Furthermore it prevented some of the catecholamine mediated effects, such as increase in blood pressure, heart rate and blood glucose.
研究了术前输注酒精对慢性酒精中毒患者芬太尼镇痛补充需求的影响。慢性酒精中毒患者定义为每日规律饮用纯酒精超过70克至少3年的人。所研究患者的年平均酒精摄入量为52升纯酒精。发现芬太尼需求与酒精摄入量之间呈正相关。与非酒精性患者相比，酒精性患者达到满意镇痛所需的芬太尼量（“饱和剂量”）显著更高（61%）。一旦实现稳定麻醉，酒精性和非酒精性患者的维持剂量相同。术前输注酒精显著减少了酒精性和非酒精性患者达到麻醉所需的芬太尼量（分别减少25%和29%）。此外，它还预防了一些儿茶酚胺介导的效应，如血压、心率和血糖升高。
