Busolo F, Zanchetta R, Lanzone E, Cusinato R
Andrologia. 1984 May-Jun;16(3):269-75. doi: 10.1111/j.1439-0272.1984.tb00282.x.
A microbiological examination has been carried out in 116 patients with unexplained infertility and with asymptomatic bacteriospermia. Organisms more frequently isolated were Staphylococcus epidermidis (81.9%), non hemolytic streptococci (23.3%), diphtheroids (25%) and alpha-hemolytic streptococci (18.1%). None of the 103 patients were positive for C. trachomatis. Mycoplasmas were isolated in 56 (48.3%) of the 116 examined samples, U. urealyticum was present in 49 (42.2%), M. hominis in 3 (2.6%) and both species in 4 (3.5%) samples of examined fluids. Forty-one of the 56 mycoplasmas-positive patients have been treated with doxycycline therapy. The treatment improved motility and caused decrease of coiled tails in 12 cases. Conception occurred in 5 (26.3%) of the 19 treated patients whose cultures were negative for mycoplasmas. These 5 pregnancies occurred in the patients that had high titers (greater than 10(5) c.c.u./ml) of ureaplasmas and in which the antibiotic therapy was successful. No pregnancy was seen in the other 22 patients where treatment failed to eradicate mycoplasmas.
对116例不明原因不孕且无症状菌精症患者进行了微生物学检查。分离出频率较高的微生物有表皮葡萄球菌（81.9%）、非溶血性链球菌（23.3%）、类白喉杆菌（25%）和α-溶血性链球菌（18.1%）。103例患者沙眼衣原体均为阴性。在116份检测样本中，56份（48.3%）分离出支原体，其中解脲脲原体存在于49份（42.2%）样本中，人型支原体存在于3份（2.6%）样本中，两种支原体均存在于4份（3.5%）检测液样本中。56例支原体阳性患者中的41例接受了强力霉素治疗。治疗改善了精子活力，12例患者的卷曲尾精子数量减少。19例接受治疗且支原体培养阴性的患者中有5例（26.3%）受孕。这5例妊娠发生在脲原体滴度高（大于10⁵ c.c.u./ml）且抗生素治疗成功的患者中。在另外22例治疗未能根除支原体的患者中未见到妊娠。
