Leviton A, Gilles F H
Ann Neurol. 1984 Jul;16(1):1-8. doi: 10.1002/ana.410160102.
Between 36 and 44 weeks after conception, telencephalic white matter in the newborn appears to be particularly vulnerable to insults that result in morphological disturbances. Available evidence indicates that this disorder (or group of disorders), named acquired perinatal leukoencephalopathy, reflects a decrease in blood flow through the distal vessels supplying paraventricular white matter and/or a metabolic disturbance produced by, or in response to, an infectious agent. Major advances in our understanding of the causes, mechanisms, and sequelae of acquired perinatal leukoencephalopathy may be made in the next decade because of improvement in brain imaging techniques, improved survival of high-risk babies, and relatively routine follow-up of these high-risk babies.
在受孕后36至44周之间，新生儿的端脑白质似乎特别容易受到导致形态紊乱的损伤。现有证据表明，这种疾病（或一组疾病），即获得性围产期白质脑病，反映了供应脑室旁白质的远端血管血流量减少和/或由感染因子引起或针对感染因子产生的代谢紊乱。由于脑成像技术的改进、高危婴儿存活率的提高以及对这些高危婴儿相对常规的随访，在未来十年我们对获得性围产期白质脑病的病因、机制和后遗症的理解可能会取得重大进展。
