Leviton A, Gilles F H
Am J Pathol. 1971 Nov;65(2):303-9.
The ages at death of neonates with various constellations of those abnormalities of cerebral white matter thought to represent a response to injury have been compared to determine the temporal relationships of the various morphologic expressions of perinatal telencephalic leukoencephalopathy. The maximum risk of hypertrophic astrocytes (HA) without amphophilic globules (GL) preceded the maximum risk of HA with GL. Of all infants with HA and GL, those without necrotic foci (NF) tended to die at a younger age than those with NF. These and other findings have been interpreted as evidence that perinatal telencephalic leukoencephalopathy may consist of several morphologic constellations whose differences may reflect variations in (a) the time of occurrence of an insult, (b) the duration of an insult or (c) the survival after an insult.
为确定围生期端脑白质脑病各种形态学表现的时间关系，对那些被认为是对损伤反应的脑白质异常不同组合的新生儿死亡年龄进行了比较。无嗜酸性小球（GL）的肥大星形细胞（HA）的最大风险先于有GL的HA的最大风险。在所有有HA和GL的婴儿中，无坏死灶（NF）的婴儿往往比有NF的婴儿死亡年龄更小。这些及其他发现被解释为证据，表明围生期端脑白质脑病可能由几种形态学组合构成，其差异可能反映出（a）损伤发生时间、（b）损伤持续时间或（c）损伤后存活情况的变化。
