Maxwell M H, Kushiro T, Dornfeld L P, Tuck M L, Waks A U
Arch Intern Med. 1984 Aug;144(8):1581-4.
A controlled prospective study compared two groups of obese hypertensive subjects during 12 weeks of a hypocaloric protein-supplemented fast containing 40 mEq of sodium daily. One group received additional sodium chloride sufficient to maintain baseline sodium intake measured prior to the fast (210 m/Eq/day). Sodium restriction resulted in greater weight loss and slightly greater BP reduction only during the initial week of fasting. Thereafter, despite sodium equilibrium, further substantial weight loss and BP reduction were identical in both groups, the decrement in weight being linear (1.89 kg/wk) and the BP reduction asymptotic. Although the initial reduction in BP during the first week of supplemented fast may be attributable to negative salt and water balance, the further reduction in BP during a period of constant sodium balance must be caused by weight loss per se or by the triggering of other antihypertensive mechanisms associated with weight reduction.
一项对照前瞻性研究比较了两组肥胖高血压受试者，他们在为期12周的低热量补充蛋白质禁食期间，每天摄入40 mEq钠。一组额外摄入氯化钠，以维持禁食前测量的基线钠摄入量（210 mEq/天）。钠限制仅在禁食的最初一周导致更大的体重减轻和略大的血压降低。此后，尽管钠平衡，但两组进一步的显著体重减轻和血压降低是相同的，体重下降呈线性（1.89 kg/周），血压降低呈渐近性。虽然在补充禁食的第一周血压的最初降低可能归因于负盐和水平衡，但在钠平衡恒定期间血压的进一步降低一定是由体重减轻本身或与体重减轻相关的其他降压机制的触发引起的。
