Klug H
Arch Geschwulstforsch. 1984;54(3):209-17.
A cellular transformation phenomenon in keratinocytes based on electron microscopic studies of human cutaneous malignant melanoma is described. In contrast only minimal reactions of this kind were observed in lentigo maligna. The histologic features of the transformation were manifest first by striking enlargement of the nucleus and nucleolus as well as by changes in chromatin structures and the formation of nuclear bodies. The cytoplasmic reaction began with degradation at desmosomes and tonofilaments. A subsequent increase in the number of mitochondria was noted. Moreover, the cytoplasm contained numerous melanosomes, so many in fact that these cells were indistinguishable in their ultrastructure from true tumor cells. In addition to melanosomes, it is quite possible that nuclear substances, which may be responsible for the transformation, are transferred to the neighbouring keratinocytes.
基于对人类皮肤恶性黑色素瘤的电子显微镜研究，描述了角质形成细胞中的一种细胞转化现象。相比之下，在恶性雀斑样痣中仅观察到极少的此类反应。转化的组织学特征首先表现为细胞核和核仁显著增大，以及染色质结构的变化和核体的形成。细胞质反应始于桥粒和张力丝的降解。随后注意到线粒体数量增加。此外，细胞质中含有大量黑素小体，事实上数量如此之多，以至于这些细胞在超微结构上与真正的肿瘤细胞无法区分。除黑素小体外，很可能负责转化的核物质被转移到相邻的角质形成细胞中。
