Goon H K, Cohen D H, Harvey J G
Aust Paediatr J. 1984 Mar;20(1):17-21. doi: 10.1111/j.1440-1754.1984.tb00030.x.
Twenty-seven cases of thoracic neuroblastoma were reviewed. Thirteen cases (48%) survived, 11 for more than 2 years and two for more than 14 months. Surgery is the treatment of choice and complete excision appears to give the best result. However, radical surgery is discouraged if the tumor is not readily removable. The use of chemotherapy and radiotherapy should be limited to Stage III and Stage IV disease and for palliation of soft tissue and bony secondaries. The clinical presentation was generally non-specific with respect to the final diagnosis in this series. Significantly raised catecholamines were seen in 13 of 16 patients assessed (81%). Prognosis was related to the age at diagnosis, stage of disease and the histological type. The better prognosis seen in thoracic neuroblastoma in comparison with abdominal neuroblastoma may be related to the earlier presentation of the disease and the higher incidence of better differentiated tumours in the thorax. There appears to be an unknown additional factor that confers a better prognosis in patients under 1 year old.
对27例胸段神经母细胞瘤病例进行了回顾性研究。13例（48%）存活，其中11例存活超过2年，2例存活超过14个月。手术是首选治疗方法，完整切除似乎能取得最佳效果。然而，如果肿瘤不易切除，则不鼓励进行根治性手术。化疗和放疗的应用应限于Ⅲ期和Ⅳ期疾病以及用于缓解软组织和骨转移灶。在本系列中，临床表现对于最终诊断通常不具有特异性。在16例接受评估的患者中，13例（81%）的儿茶酚胺显著升高。预后与诊断时的年龄、疾病分期和组织学类型有关。与腹部神经母细胞瘤相比，胸段神经母细胞瘤预后较好可能与疾病出现较早以及胸部高分化肿瘤的发生率较高有关。似乎存在一个未知的额外因素，使得1岁以下患者的预后更好。
