Kramer P H, Chatterjee K, Schwartz A, Swedberg K, Rouleau J L, Curran D, Blevins L, Parmley W W
Br Heart J. 1984 Sep;52(3):308-13. doi: 10.1136/hrt.52.3.308.
Changes in coronary haemodynamics and angina threshold were determined during atrial pacing in 11 patients with fixed obstructive coronary artery disease with effort angina before and after the administration of 20 mg of oral nifedipine. Coronary vascular resistance decreased at resting and at "subangina" heart rates but not at "angina" rates. Primary coronary vasodilatation with nifedipine was also suggested by higher coronary sinus oxygen content whether at rest or at subangina or angina heart rates. After nifedipine angina occurred at a lower double product and lower myocardial oxygen consumption. These findings suggest that nifedipine is a coronary vasodilator, but angina can occur at a lower angina threshold in some patients with obstructive coronary artery disease.
在11例患有固定性阻塞性冠状动脉疾病并伴有劳力性心绞痛的患者中，在口服20毫克硝苯地平前后，通过心房起搏测定冠状动脉血流动力学和心绞痛阈值的变化。静息时以及“亚心绞痛”心率时冠状动脉血管阻力降低，但在“心绞痛”心率时未降低。无论静息时、亚心绞痛或心绞痛心率时，较高的冠状窦氧含量也提示硝苯地平有原发性冠状动脉血管扩张作用。服用硝苯地平后，心绞痛在较低的心率血压乘积和较低的心肌耗氧量时发生。这些发现提示硝苯地平是一种冠状动脉血管扩张剂，但在一些阻塞性冠状动脉疾病患者中，心绞痛可在较低的心绞痛阈值时发生。
