Emanuelsson H, Hjalmarson A, Holmberg S, Waagstein F
Eur Heart J. 1984 Apr;5(4):308-16. doi: 10.1093/oxfordjournals.eurheartj.a061657.
In order to study the systemic and coronary haemodynamic effects of felodipine, a new dihydropyridine derivative, 10 patients with coronary artery disease were studied during cardiac catheterization. Measurements were performed at rest and during pacing-induced angina pectoris. At rest, the heart rate rose from 70 +/- 20 to 78 +/- 20 (P less than 0.05), the systemic arterial pressure decreased by about 20% (P less than 0.01) and the cardiac index rose from 2.9 +/- 1.2 to 4.0 +/- 1.0 (P less than 0.05). The coronary sinus flow (CSF) increased about 50% (P less than 0.01). During pacing to the same heart rate as in the control measurements, felodipine induced similar changes in systemic haemodynamic values as in the resting position. Myocardial lactate extraction and ST segment depression were not significantly altered. After felodipine, the pacing rate could be further increased in 7 patients as compared with the control value. Both systemic and coronary effects were then very similar compared with those during the lower pacing rate. In conclusion, felodipine is a very potent systemic and coronary vasodilator with potential value in the treatment of hypertension and cardiac failure. The drug may also be of value in the treatment of ischaemic heart disease, but further studies with titration of optimal doses are needed in that respect.
为研究新型二氢吡啶衍生物非洛地平对全身及冠状动脉血流动力学的影响，对10例冠心病患者在心脏导管插入术期间进行了研究。在静息状态和起搏诱发心绞痛时进行测量。静息时，心率从70±20次/分钟升至78±20次/分钟（P<0.05），全身动脉压下降约20%（P<0.01），心脏指数从2.9±1.2升至4.0±1.0（P<0.05）。冠状窦血流量（CSF）增加约50%（P<0.01）。在起搏至与对照测量相同心率时，非洛地平引起的全身血流动力学值变化与静息时相似。心肌乳酸摄取和ST段压低无明显改变。服用非洛地平后，7例患者的起搏率可较对照值进一步提高。此时，全身和冠状动脉效应与较低起搏率时非常相似。总之，非洛地平是一种非常有效的全身和冠状动脉血管扩张剂，在治疗高血压和心力衰竭方面具有潜在价值。该药在治疗缺血性心脏病方面可能也有价值，但在这方面需要进一步研究以确定最佳剂量。
