Behnia R, Koushanpour E, Goldstick T K, Linde H W, Osborn R
Br J Anaesth. 1984 Sep;56(9):1037-43. doi: 10.1093/bja/56.9.1037.
Renal oxygenation was studied during induced hypotension in mongrel dogs, anaesthetized with 1-1.5% halothane in oxygen. Hypotension was induced with an infusion i.v. of sodium nitroprusside (SNP) 70 +/- 17 micrograms kg-1 min-1 (mean +/- SEM) or trimetaphan (TMP) 36 +/- 16 micrograms kg-1 min-1, or by controlled arterial haemorrhage (45 +/- 6 ml/kg of body weight). Mean arterial pressure (MAP), cortical (Pcto2) and medullary (Pmto2) tissue oxygen tensions, arterial (Pao2), renal venous (Prvo2), and urine (Puo2) oxygen tensions were measured during the 40-min control, hypotension, and recovery periods. MAP was decreased to approximately 60% of the control value. Pcto2 decreased significantly (P less than 0.05) in all three groups while Pmto2 decreased significantly only in the haemorrhage group. Upon restoration of MAP to normal values, renal tissue oxygen tensions recovered in all groups, somewhat more rapidly in the SNP group. There were no significant differences in Pao2, Prvo2, and Puo2 during control, hypotension and recovery periods in the three groups. Tissue oxygen tension values followed the changes in MAP, but were not hypoxic, leading us to believe that both SNP and TMP are hypotensive agents safe for the kidney.
在杂种犬中研究了诱导性低血压期间的肾氧合情况，这些犬用含1 - 1.5%氟烷的氧气麻醉。通过静脉输注硝普钠（SNP）70±17微克/千克·分钟（均值±标准误）或阿方那特（TMP）36±16微克/千克·分钟诱导低血压，或通过控制性动脉出血（45±6毫升/千克体重）诱导低血压。在40分钟的对照期、低血压期和恢复期测量平均动脉压（MAP）、皮质组织氧分压（Pcto2）和髓质组织氧分压（Pmto2）、动脉血氧分压（Pao2）、肾静脉血氧分压（Prvo2）和尿氧分压（Puo2）。MAP降至对照值的约60%。所有三组中Pcto2均显著降低（P＜0.05），而仅出血组的Pmto2显著降低。当MAP恢复到正常值时，所有组的肾组织氧分压均恢复，SNP组恢复得稍快一些。三组在对照期、低血压期和恢复期的Pao2、Prvo2和Puo2无显著差异。组织氧分压值随MAP变化，但未出现缺氧情况，这使我们相信SNP和TMP都是对肾脏安全的降压药。
