Tremper K K, Waxman K S, Applebaum R A, Konchigeri H N, Zaccari J, Hufstedler S M, Farnum M
Crit Care Med. 1985 Feb;13(2):65-7. doi: 10.1097/00003246-198502000-00001.
To determine the effect of vasodilator-induced hypotension on the relationship between transcutaneous PO2 (PtcO2) and PaO2, six mongrel dogs and 20 patients were monitored before and during infusion of sodium nitroprusside (SNP), with PtcO2 sensors heated to 45 degrees C. First, SNP infusion was used to lower the mean arterial pressure (MAP) of anesthetized dogs, in steps of approximately 25%, to 49 +/- 3 (SD) mm Hg. There were no significant changes in cardiac output, oxygen consumption, PtcO2, PaO2, or PtcO2 index (PtcO2/PaO2). Twenty patients were monitored during general anesthesia. Fifteen patients were being treated for acute hypertension with SNP, and in five patients hypotension was induced with SNP to minimize blood loss. There was a significant decrease in MAP, PaO2, and PtcO2, and a significant increase in alveolar-arterial PO2 difference during SNP infusion. PtcO2 index did not change significantly from its preinfusion value in either group.
为了确定血管扩张剂诱导的低血压对经皮氧分压（PtcO2）与动脉血氧分压（PaO2）之间关系的影响，对6只杂种犬和20例患者在输注硝普钠（SNP）之前和期间进行了监测，将PtcO2传感器加热至45摄氏度。首先，使用SNP输注逐步将麻醉犬的平均动脉压（MAP）降低约25%，至49±3（标准差）毫米汞柱。心输出量、氧耗量、PtcO2、PaO2或PtcO2指数（PtcO2/PaO2）均无显著变化。对20例患者在全身麻醉期间进行了监测。15例患者因急性高血压接受SNP治疗，5例患者使用SNP诱导低血压以尽量减少失血。在输注SNP期间，MAP、PaO2和PtcO2显著降低，肺泡-动脉血氧分压差显著增加。两组的PtcO2指数与输注前值相比均无显著变化。
