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[兔小肠对霍乱毒素和沙门氏菌毒素反应分泌液的色谱-质谱研究]

[Chromato-mass-spectral study of the secretion in the rabbit small intestine discharged in response to cholera and salmonella toxins].

作者信息

Linberg L F, Arsen'eva L S, Iurkiv V A, Pokrovskiĭ V I

出版信息

Biull Eksp Biol Med. 1984 Jul;98(7):44-6.

PMID:6466829
Abstract

A study was made of rabbit small intestine secretion induced by cholera and salmonellosis toxins. Application of electron impact mass-spectrometry and chemical ionization permitted identification of 9 and structure assignment for 14 out of 27 secretion components. The assay demonstrated the major part of the components to be the monosaccharides, glucose and galactose. Fatty acids, cholesterol and hydroxyacids were found to be present in negligible amounts. It was discovered that the action of the toxins primarily affected the metabolism of unsaturated fatty acids.

摘要

对霍乱毒素和沙门氏菌病毒素诱导的兔小肠分泌物进行了研究。应用电子轰击质谱法和化学电离法能够鉴定出27种分泌物成分中的9种,并确定其中14种成分的结构。分析表明,这些成分的主要部分是单糖、葡萄糖和半乳糖。发现脂肪酸、胆固醇和羟基酸的含量极少。研究发现,毒素的作用主要影响不饱和脂肪酸的代谢。

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