Golenko O D, Paramonova T D, Nikolaeva T G
Biull Eksp Biol Med. 1984 Jul;98(7):59-61.
Autoradiography (3H-thymidine) and DNA-cytofluorometry were used to study the effect of quinoline dibromide (QD), a potential inhibitor of cobalamine-dependent methionine synthetase, on the kinetics of cell proliferation of L-1210 mouse leukemia. QD was found to produce the secondary blockade of leukemic cells in the late S-phase of the mitotic cycle. Such a mechanism of QD action promoted the potentiation of antitumor activity of the antimetabolites methotrexate, cytosine arabinoside and 5-fluorouracil during combined chemotherapy.
利用放射自显影术（³H-胸腺嘧啶核苷）和DNA细胞荧光测定法，研究钴胺素依赖性甲硫氨酸合成酶的潜在抑制剂二溴喹啉（QD）对L-1210小鼠白血病细胞增殖动力学的影响。发现QD可在有丝分裂周期的S期晚期对白血病细胞产生继发性阻断。QD的这种作用机制在联合化疗期间增强了抗代谢药物甲氨蝶呤、阿糖胞苷和5-氟尿嘧啶的抗肿瘤活性。
