Petrov S A
Arkh Patol. 1994 Mar-Apr;56(2):25-7.
22 mice with L-1210 leukemia treated with quinoline dibromide were studied histologically. Two ways of the development of leptomeningeal infiltrates in the brain are established. The first is due to the growth of uninhibited by treatment bone-marrow leukemic infiltrates (LI) of the skull, while the second-when the above infiltrates are suppressed-due to the proliferation of leukemic cells penetrating from the dura mater to the leptomeninges protected by the hematoencephalic barrier from the effect of anticancer drugs. when the recurrence of leukemia occurs the growth of bone-marrow LI continues resulting in the additional migration of leukemic cells to the leptomeninges. These ways of the leptomeninx LI formation should be taken into consideration in the leukemia treatment.
对22只接受二溴喹啉治疗的L - 1210白血病小鼠进行了组织学研究。确定了白血病细胞在脑软脑膜浸润发展的两种方式。第一种是由于颅骨骨髓白血病浸润（LI）不受治疗抑制地生长，而第二种是当上述浸润被抑制时，由于白血病细胞从硬脑膜增殖穿透到受血脑屏障保护免受抗癌药物影响的软脑膜。当白血病复发时，骨髓LI继续生长，导致白血病细胞向软脑膜额外迁移。在白血病治疗中应考虑软脑膜LI形成的这些方式。
