Aĭlamazian E K, Taranova N P, Zhuravlev A V, Kirchik O S
Biull Eksp Biol Med. 1984 Jul;98(7):93-4.
The authors studied the possibility of 14C-phospholipid transplacental penetration after 15C-phospholipid injection into rats at the 20th day of pregnancy. The preparation of 14C-phospholipids (total phospholipids) was isolated by thin-layer chromatography from the liver of rats injected with 2-14C-sodium acetate. One hour after its injection into the rat, 14C-phospholipids were detectable in total phospholipids of the pulmonary and cerebral fetal tissues. It was discovered that specific radioactivity of phospholipids contained by these tissues was 2--5 times higher when 14C-phospholipids were injected subcutaneously as compared with intramuscular injection. It is concluded that exogenous phospholipids entrapped in the mother's circulation penetrate the placental barrier of the fetus and the blood-brain barrier of the mature fetus, being consumed by different fetal tissues for forming membrane structures of the fetal tissues.
作者研究了在妊娠第20天给大鼠注射15C - 磷脂后，14C - 磷脂经胎盘渗透的可能性。用薄层色谱法从注射了2 - 14C - 醋酸钠的大鼠肝脏中分离出14C - 磷脂（总磷脂）制剂。在给大鼠注射14C - 磷脂1小时后，在胎儿肺和脑的总磷脂中可检测到14C - 磷脂。发现与肌肉注射相比，皮下注射14C - 磷脂时，这些组织中所含磷脂的比放射性高2至5倍。得出的结论是，母体循环中截留的外源性磷脂可穿透胎儿的胎盘屏障和成熟胎儿的血脑屏障，被不同的胎儿组织消耗以形成胎儿组织的膜结构。
