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[胰腺蛋白酶的蛋白质抑制剂对成年大鼠肠道中免疫反应性鸡卵清蛋白分解及吸收的影响]

[Effect of protein inhibitors of pancreatic proteinases on the breakdown and absorption of immunoreactive chicken ovalbumin in the intestines of adult rats].

作者信息

Sadykova R E, Gmoshinskiĭ I V, Mazo V K, Shaternikov V A

出版信息

Biull Eksp Biol Med. 1984 Aug;98(8):194-6.

PMID:6466856
Abstract

Adult male Wistar rats received protein mixtures containing chick ovalbumin (OVA) intragastrically, whereupon immunoreactive OVA was determined in the chymus of the gastrointestinal tract and in blood serum by the immunofluorescence technique and radioimmunoassay. Combined administration of OVA and the soybean inhibitor of trypsin suppressed the degradation of the antigenic structure of OVA in the intestine and augmentation of immunoreactive protein absorption. The suppression was less pronounced if OVA was combined with chick ovomucoid.

摘要

成年雄性Wistar大鼠经胃内给予含鸡卵清蛋白(OVA)的蛋白质混合物,随后通过免疫荧光技术和放射免疫测定法测定胃肠道乳糜和血清中的免疫反应性OVA。OVA与大豆胰蛋白酶抑制剂联合给药可抑制肠道中OVA抗原结构的降解以及免疫反应性蛋白质吸收的增加。如果OVA与鸡卵类粘蛋白联合使用,这种抑制作用则不太明显。

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