Lapin I P
Biull Eksp Biol Med. 1984 Aug;98(8):206-9.
Intracerebroventricular injection of 1-kynurenine sulfate (10 micrograms) eliminated anticaffeine effect of diazepam (5, 10 and 20 mg/kg) in mice. Antipentylenetetrazole (0.5-2.5 mg/kg) and anticonflict (1-2.5 mg/kg) effects of diazepam were not altered by kynurenine (0.1-10 micrograms). The sedative effect of diazepam (1 and 4 mg/kg) was potentiated by kynurenine (1 microgram). Stimulation of locomotion induced by kynurenine (0.5 and 2.5 micrograms) was prevented or perversed by pretreatment with diazepam (1 mg/kg). In a conflict situation test, diazepam and kynurenine had an opposite action, respectively increasing and decreasing the number of transitions between light and dark compartments. The central effects of kynurenine can be related and not related to benzodiazepine receptors.
向小鼠脑室内注射硫酸犬尿氨酸（10微克）可消除地西泮（5、10和20毫克/千克）的抗咖啡因作用。犬尿氨酸（0.1 - 10微克）不会改变地西泮的抗戊四氮（0.5 - 2.5毫克/千克）和抗冲突（1 - 2.5毫克/千克）作用。犬尿氨酸（1微克）增强了地西泮（1和4毫克/千克）的镇静作用。地西泮（1毫克/千克）预处理可预防或逆转犬尿氨酸（0.5和2.5微克）诱导的运动刺激。在冲突情境测试中，地西泮和犬尿氨酸具有相反的作用，分别增加和减少明暗隔间之间的转换次数。犬尿氨酸的中枢作用可能与苯二氮䓬受体有关，也可能无关。
