Thomas J V, Gragoudas E S, Blair N P, Lapus J V
Arch Ophthalmol. 1978 Apr;96(4):625-8. doi: 10.1001/archopht.1978.03910050321005.
One hundred twenty-eight consecutive aphakic glaucomatous eyes of 91 patients were examined by fluorescein angiography. Macular edema was present in 16 (28%) of 56 eyes currently being treated with epinephrine and 9 (13%) of 72 eyes not currently being treated with epinephrine. This difference is statistically significant at the 95% confidence level. Epinephrine therapy was discontinued in seven eyes with macular edema. A follow-up of these patients for six months to one year with serial anglograms showed resolution of edema in six of seven eyes. In one eye without macular edema, administration of epinephrine was associated with appearance of edema. Discontinuing epinephrine therapy was associated with resolution of edema. No significant correlation was found between use of other antiglaucomatous medications and macular edema. It is evident from this study that there is statistical support for the concept of an epinephrine-induced macular edema.
对91例患者的128只连续性无晶状体青光眼患眼进行了荧光素血管造影检查。在目前正在使用肾上腺素治疗的56只眼中，有16只（28%）出现黄斑水肿；在目前未使用肾上腺素治疗的72只眼中，有9只（13%）出现黄斑水肿。在95%置信水平下，这种差异具有统计学意义。对7只出现黄斑水肿的眼睛停用了肾上腺素治疗。对这些患者进行了为期6个月至1年的随访，并进行系列血管造影检查，结果显示7只眼中有6只的水肿消退。在1只未出现黄斑水肿的眼睛中，使用肾上腺素后出现了水肿。停用肾上腺素治疗与水肿消退相关。未发现使用其他抗青光眼药物与黄斑水肿之间存在显著相关性。从这项研究可以明显看出，肾上腺素诱发黄斑水肿这一概念有统计学依据。
