Ling C C, Spiro I J, Stickler R
Br J Radiol. 1984 Aug;57(680):723-8. doi: 10.1259/0007-1285-57-680-723.
A dose-rate effect is observed between 1 and 10 Gy/min for cultured Chinese hamster V-79 fibroblast cells irradiated under pO2 levels of less than 10 ppm, 100 ppm, 300 ppm and 21%. The dose for a cellular surviving fraction of 0.1% increases by 10-15% as the dose rate is changed from 10 to 1 Gy/min. This observed dose-rate effect is consistent with the repair of sublethal damage taking place during the radiation delivery. A related finding is that acute hypoxia in cell culture does not inhibit sublethal damage repair.
在低于10 ppm、100 ppm、300 ppm和21%的pO2水平下照射培养的中国仓鼠V - 79成纤维细胞时，在1至10 Gy/分钟之间观察到剂量率效应。当剂量率从10变为1 Gy/分钟时，细胞存活分数为0.1%的剂量增加了10 - 15%。观察到的这种剂量率效应与辐射传递过程中发生的亚致死损伤修复一致。一个相关的发现是细胞培养中的急性缺氧并不抑制亚致死损伤修复。
