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神经切断对相邻神经脊髓分布的影响。

Effect of nerve section on the spinal distribution of neighboring nerves.

作者信息

Seltzer Z, Devor M

出版信息

Brain Res. 1984 Jul 23;306(1-2):31-7. doi: 10.1016/0006-8993(84)90353-6.

DOI:10.1016/0006-8993(84)90353-6
PMID:6466981
Abstract

The spinal cord distribution of axonal terminals of peripheral nerves that innervate the skin of the upper medial thigh was examined in rats using transganglionic transport of horseradish peroxidase (HRP) and wheat-germ agglutinin-conjugated HRP (WGA-HRP). Chronic transection of the sciatic nerve or both the sciatic and saphenous nerves did not alter this distribution. Therefore, long-distance sprouting of intact 'thigh nerve' afferents in the dorsal horn is apparently not the mechanism whereby spinal dorsal horn neurons deafferented by sciatic and saphenous neurectomy, gain novel receptive fields in the cutaneous distribution of neighbouring intact nerves of the thigh.

摘要

利用辣根过氧化物酶(HRP)和小麦胚芽凝集素结合的HRP(WGA-HRP)的跨神经节运输,在大鼠中检查了支配大腿内侧上部皮肤的外周神经轴突终末的脊髓分布。坐骨神经或坐骨神经和隐神经的慢性横断并未改变这种分布。因此,完整的“大腿神经”传入纤维在背角的长距离发芽显然不是坐骨神经和隐神经切除术导致去传入的脊髓背角神经元在大腿相邻完整神经的皮肤分布中获得新感受野的机制。

相似文献

1
Effect of nerve section on the spinal distribution of neighboring nerves.神经切断对相邻神经脊髓分布的影响。
Brain Res. 1984 Jul 23;306(1-2):31-7. doi: 10.1016/0006-8993(84)90353-6.
2
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Eur J Neurosci. 1994 Jan 1;6(1):75-86. doi: 10.1111/j.1460-9568.1994.tb00249.x.
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Central projections of the sciatic, saphenous, median, and ulnar nerves of the rat demonstrated by transganglionic transport of choleragenoid-HRP (B-HRP) and wheat germ agglutinin-HRP (WGA-HRP).通过霍乱毒素-HRP(B-HRP)和小麦胚芽凝集素-HRP(WGA-HRP)的跨神经节运输显示大鼠坐骨神经、隐神经、正中神经和尺神经的中枢投射。
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Somatotopic organization of cutaneous afferent terminals and dorsal horn neuronal receptive fields in the superficial and deep laminae of the rat lumbar spinal cord.大鼠腰段脊髓浅、深层皮肤传入神经终末和背角神经元感受野的躯体定位组织
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Spinal cord projections from hindlimb muscle nerves in the rat studied by transganglionic transport of horseradish peroxidase, wheat germ agglutinin conjugated horseradish peroxidase, or horseradish peroxidase with dimethylsulfoxide.通过辣根过氧化物酶、小麦胚芽凝集素结合辣根过氧化物酶或含二甲基亚砜的辣根过氧化物酶的跨神经节运输对大鼠后肢肌肉神经的脊髓投射进行研究。
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Collateral sprouting of the central terminals of cutaneous primary afferent neurons in the rat spinal cord: pattern, morphology, and influence of targets.大鼠脊髓中皮肤初级传入神经元中枢终末的侧支发芽:模式、形态及靶标的影响
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The sprouting of saphenous nerve terminals in the spinal cord following early postnatal sciatic nerve section in the rat.大鼠出生后早期坐骨神经切断后脊髓中隐神经终末的发芽
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Growth-associated protein 43 immunoreactivity in the superficial dorsal horn of the rat spinal cord is localized in atrophic C-fiber, and not in sprouted A-fiber, central terminals after peripheral nerve injury.大鼠脊髓背角浅层中生长相关蛋白43免疫反应性定位于萎缩的C纤维,而非外周神经损伤后芽生的A纤维中枢终末。
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引用本文的文献

1
Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve.周围神经损伤会激活来自相邻完整神经的向背角神经元汇聚的伤害性输入。
Exp Brain Res. 2015 Apr;233(4):1201-12. doi: 10.1007/s00221-015-4203-2. Epub 2015 Jan 20.
2
Collateral sprouting of uninjured primary afferent A-fibers into the superficial dorsal horn of the adult rat spinal cord after topical capsaicin treatment to the sciatic nerve.在对成年大鼠坐骨神经进行局部辣椒素处理后,未受损的初级传入A纤维向成年大鼠脊髓背角浅层的侧支发芽。
J Neurosci. 1996 Aug 15;16(16):5189-95. doi: 10.1523/JNEUROSCI.16-16-05189.1996.