Koller K J, Coyle J T
Brain Res. 1984 Jul;317(1):137-40. doi: 10.1016/0165-3806(84)90150-0.
The levels of N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG) were measured in several regions and in whole brain of rats from 15 days of gestation (DG) to adulthood by means of an isocratic HPLC method. The levels of NAAG in whole brain increased 3-fold between 15 DG and birth, which was 90% of the adult level. Whereas the levels of NAAG in spinal cord increased from 2 days to 4 weeks after birth, in forebrain regions the levels increased 2-3-fold between 2 and 8 days after birth and then declined substantially to adult levels. In contrast, in whole brain and in the several regions examined after birth, the levels of NAA rose steadily from 15 DG to adulthood with a 30-fold increase in whole brain concentration. The results of this study demonstrate the lack of correlation in the development of NAA and NAAG levels and suggest that NAAG is localized in a cell system that matures early.
采用等度高效液相色谱法，测定了从妊娠第15天（DG）到成年大鼠几个脑区及全脑的N-乙酰天门冬氨酸（NAA）和N-乙酰天门冬氨酰谷氨酸（NAAG）水平。全脑中NAAG水平在妊娠第15天到出生之间增加了3倍，达到成年水平的90%。而脊髓中NAAG水平在出生后2天到4周升高，在前脑区域，其水平在出生后2至8天增加2至3倍，然后大幅下降至成年水平。相比之下，出生后在全脑及几个检测脑区中，NAA水平从妊娠第15天到成年稳步上升，全脑浓度增加了30倍。本研究结果表明，NAA和NAAG水平的发育缺乏相关性，并提示NAAG定位于一个早期成熟的细胞系统中。
