Amornmarn R, Prempree T, Jaiwatana J, Wizenberg M J
Cancer. 1984 Oct 1;54(7):1293-9. doi: 10.1002/1097-0142(19841001)54:7<1293::aid-cncr2820540711>3.0.co;2-4.
This is a retrospective analysis of 185 patients with squamous cell carcinoma of the tonsillar region treated at the Department of Radiation Oncology, University of Maryland Hospital from 1956 to 1977. All patients were treated by one of the following: (1) external beam therapy alone; or (2) combined external beam and interstitial brachytherapy. Five-year disease-free survivals, for early Stages (I and II), are 100% and 73%, comparable to the other series published in the literature. However, in advanced Stages III and IV, survival data showed 52% and 21%, respectively, 5-year disease-free survival better than any other reports. It is thought that the special interest of the authors in interstitial brachytherapy and a well-integrated plan of external beam and brachytherapy is responsible for this success. The local control rate for T1, T2, T3, and T4 was 94%, 88%, 62%, and 19%, respectively, with the overall regional control rate of 83%. The prognostic factors appear to be related to the T-factor, N-factor, radiation dose, and method of treatment given, and the degree of tongue involvement. The detailed analysis of survivals and failures in the light of dosimetric study is presented along with some example cases of interstitial brachytherapy.
这是一项对185例扁桃体区域鳞状细胞癌患者的回顾性分析，这些患者于1956年至1977年在马里兰大学医院放射肿瘤学系接受治疗。所有患者均接受以下治疗之一：（1）单纯外照射治疗；或（2）外照射与组织间近距离放射治疗联合应用。早期（I期和II期）患者的5年无病生存率分别为100%和73%，与文献中发表的其他系列研究结果相当。然而，在III期和IV期晚期患者中，生存数据分别显示为52%和21%，5年无病生存率优于其他任何报告。据认为，作者对组织间近距离放射治疗的特别关注以及外照射和近距离放射治疗的良好综合方案是取得这一成功的原因。T1、T2、T3和T4期的局部控制率分别为94%、88%、62%和19%，总体区域控制率为83%。预后因素似乎与T因子、N因子、放射剂量、所给予的治疗方法以及舌部受累程度有关。结合剂量学研究对生存和失败情况进行了详细分析，并列举了一些组织间近距离放射治疗的病例。
