具有阳性H-Y抗原的无性腺症。

Agonadism with positive H-Y antigen.

作者信息

Kinoshita K, Shiina Y, Bando M, Seino K, Yamada K

出版信息

Clin Genet. 1984 Jul;26(1):61-4. doi: 10.1111/j.1399-0004.1984.tb00790.x.

DOI:10.1111/j.1399-0004.1984.tb00790.x

Abstract

A 30-year-old phenotypic female was investigated because of absence of the vagina. Her serum gonadotropins were elevated while testosterone was in the normal range for females. Stimulation with human chorionic gonadotropin (hCG) gave no response of testosterone. No uterus, Fallopian tubes, Wolffian derivatives, or the gonads were found at laparotomy. Chromosome analysis showed a 46,XY karyotype. The expression of the H-Y antigen was positive. The results suggest that testicular degeneration in agonadism is not caused by a defective H-Y antigen.

摘要

一名30岁的表型女性因阴道缺失接受检查。她的血清促性腺激素升高，而睾酮水平在女性正常范围内。用人绒毛膜促性腺激素（hCG）刺激后，睾酮无反应。剖腹探查未发现子宫、输卵管、中肾衍生物或性腺。染色体分析显示核型为46,XY。H-Y抗原表达呈阳性。结果表明，无性腺症中的睾丸退化不是由有缺陷的H-Y抗原引起的。