Noble N A, Brewer G J, Oelshlegel F J
Biochem Genet. 1978 Feb;16(1-2):39-44. doi: 10.1007/BF00484383.
We have developed two strains of hooded rats with differing erythrocyte oxygen affinities by selection on red cell 2,3-diphosphoglycerate levels. Genetic studies have shown that these strains differ at one DPG-level-determining locus. This article reports the results of a study which involved measurement of plasma cholesterol levels in rats from the strains and the F2 progeny of strain intercrosses. Low-DPG strain rats, with high oxygen affinity, had significantly higher mean cholesterol levels than High-DPG rats. Animals from the extremes of the F2 distribution of DPG levels showed similar, significantly different mean cholesterol levels, indicating that the negative association between DPG and cholesterol levels in strain rats was not due to inadvertent fixation of unrelated genes during selection on DPG. The possibility is discussed that high oxygen affinity, brought about by low DPG levels, may be causative in increasing cholesterol levels.
我们通过对红细胞2,3 - 二磷酸甘油酸（2,3 - DPG）水平进行选择，培育出了两株具有不同红细胞氧亲和力的有帽大鼠品系。遗传学研究表明，这些品系在一个决定DPG水平的基因座上存在差异。本文报告了一项研究结果，该研究涉及对这些品系以及品系杂交F2后代大鼠的血浆胆固醇水平进行测量。具有高氧亲和力的低DPG品系大鼠的平均胆固醇水平显著高于高DPG大鼠。来自DPG水平F2分布两端的动物显示出相似但显著不同的平均胆固醇水平，这表明品系大鼠中DPG与胆固醇水平之间的负相关并非由于在对DPG进行选择时无意中固定了不相关的基因。文中讨论了低DPG水平导致的高氧亲和力可能是胆固醇水平升高的原因这一可能性。
