Brewer G, Gilman J, Noble N, Crews V
Biochem Genet. 1978 Aug;16(7-8):695-707. doi: 10.1007/BF00484727.
Two sublines of commercially available Long-Evans hooded rats have been developed by genetic selection. These sublines have widely differing levels of erythrocyte 2,3-diphosphoglycerate (DPG) due to different alleles at a single genetic locus. In the present work, it is shown that rats from the commercial population are also polymorphic at a hemoglobin locus, probably involving two alleles of the IIIbeta-globin chain locus. Particular hemoglobin types have been found to be strongly associated with certain DPG types, not only in the high-DPG and low-DPG lines but also in the commercial population. Two explanations for this association are considered. One is a single-locus hypothesis, with hemoglobin allelic variation causing DPG variation, and the other is a two-locus hypothesis, with marked linkage disequilibrium.
通过基因选择培育出了两种市售的长 Evans 有帽大鼠亚系。由于单个基因座上的不同等位基因，这些亚系的红细胞 2,3 - 二磷酸甘油酸（DPG）水平差异很大。在本研究中，发现商业种群的大鼠在血红蛋白基因座上也具有多态性，可能涉及Ⅲβ - 珠蛋白链基因座的两个等位基因。不仅在高 DPG 和低 DPG 品系中，而且在商业种群中，都发现特定的血红蛋白类型与某些 DPG 类型密切相关。考虑了这种关联的两种解释。一种是单基因座假说，即血红蛋白等位基因变异导致 DPG 变异；另一种是双基因座假说，即存在明显的连锁不平衡。
