Révész L, Siracka E
Cytometry. 1984 Jul;5(4):442-4. doi: 10.1002/cyto.990050424.
The stromal, parenchymal, and vascular cellular constituents were identified and their relative proportion determined in biopsy specimens derived from untreated uterine cervix carcinomas. In the stroma of the tumors that eventually responded well to radiation treatment resulting in a prolonged survival of the patients, the proportion of vascular cells was increased in comparison to the cases that were associated with a poor patient survival. The observations were interpreted in terms of the radiobiological oxygen effect reflecting the radiosensitivity variation of cells in tumor areas vascularized to varying extent. It was concluded that the determination of a tumor vascularity index as a routine parameter would be of a great prognostic value and would contribute to the characterization of individual tumors, leading to improved therapeutic efficiency.
对未经治疗的子宫颈癌活检标本中的基质、实质和血管细胞成分进行了鉴定，并确定了它们的相对比例。在最终对放疗反应良好从而使患者生存期延长的肿瘤基质中，与患者生存期较差的病例相比，血管细胞的比例有所增加。这些观察结果根据放射生物学氧效应进行了解释，该效应反映了不同程度血管化肿瘤区域中细胞的放射敏感性差异。得出的结论是，将肿瘤血管指数作为常规参数进行测定具有很大的预后价值，有助于对个体肿瘤进行特征描述，从而提高治疗效果。
