Haffner S M, Rosenthal M, Hazuda H P, Stern M P, Franco L J
Diabetes Care. 1984 Jul-Aug;7(4):347-53. doi: 10.2337/diacare.7.4.347.
We tested the ability of three potential screening tests for diabetes (fasting plasma glucose value greater than or equal to 140 mg/dl, 1-h postglucose (PG) load value greater than or equal to 200 mg/dl, and 2-h PG value greater than or equal to 200 mg/dl) to detect non-insulin-dependent diabetes in 130 diabetic Mexican Americans (MAs) and 50 diabetic Anglo Americans (AA) using the National Diabetes Data Group criteria as the standard. The sensitivity of the fasting plasma glucose (FPG) cutpoint in detecting diabetes was low in both AAs (36.0%) and MAs (59.3%) and was related to the age-adjusted prevalence rates of diabetes in the two ethnic groups (AAs, 4.9%; MAs, 10.9%). The 2-h PG load cutpoint had good sensitivity (greater than 93%) and specificity (greater than 99%) in both ethnic groups. The ethnic difference in the sensitivity of the FPG cutpoint appeared to be related to the greater hyperglycemia of diabetic MAs compared with diabetic AAs. Nearly 30% of diabetic MAs had FPG values greater than or equal to 200 mg/dl as contrasted with only 10% of diabetic AAs. The difference in severity of hyperglycemia between the ethnic groups appears to be unrelated to ethnic differences in adiposity, pharmacologic treatment, or delay in diagnosis, although longer disease duration in MAs may explain part of the difference.
我们采用美国国家糖尿病数据组的标准，对三种潜在的糖尿病筛查测试（空腹血糖值大于或等于140毫克/分升、葡萄糖（PG）负荷后1小时值大于或等于200毫克/分升、PG负荷后2小时值大于或等于200毫克/分升）检测130名墨西哥裔美国糖尿病患者（MAs）和50名英裔美国糖尿病患者（AA）中非胰岛素依赖型糖尿病的能力进行了测试。空腹血糖（FPG）切点检测糖尿病的敏感性在AA组（36.0%）和MA组（59.3%）中均较低，且与两个种族中年龄调整后的糖尿病患病率相关（AA组为4.9%；MA组为10.9%）。PG负荷后2小时切点在两个种族中均具有良好的敏感性（大于93%）和特异性（大于99%）。FPG切点敏感性的种族差异似乎与糖尿病MA患者比糖尿病AA患者更高的高血糖水平有关。近30%的糖尿病MA患者FPG值大于或等于200毫克/分升，而糖尿病AA患者中这一比例仅为10%。种族之间高血糖严重程度的差异似乎与肥胖、药物治疗或诊断延迟方面的种族差异无关，尽管MA患者较长的病程可能解释了部分差异。
