Rossi R, Leititis J U, Hagel K J, Smolarz A, Brandis M
Eur J Pediatr. 1984 Jun;142(2):138-40. doi: 10.1007/BF00445597.
Accidental digitalis ingestion in children is a rare, but potentially life-threatening emergency. We report the case of a 2 10/12-year-old boy with accidental ingestion of 6 mg beta-Acetyl-digoxin. Soon after admission, the boy developed sinus bradycardia, SA and AV-block, of increasing severity without circulatory impairment. As the serum digoxin level reached 21.7 ng/ml digoxin-specific Fab-antibody-fragments were used to bind free serum digoxin. Immediately after infusion, serum free digoxin was below the detection limit, whereas total digoxin peaked at 219 ng/ml 5 h thereafter. The arrhythmias did not subside totally, so that in addition, a transvenous pacemaker was placed, but never used. The antibody-infusion was well tolerated and the boy was discharged in good health.
儿童意外摄入洋地黄是一种罕见但可能危及生命的紧急情况。我们报告了一例2又10/12岁男孩意外摄入6毫克β-乙酰地高辛的病例。入院后不久，该男孩出现窦性心动过缓、窦房阻滞和房室阻滞，且程度逐渐加重，但无循环障碍。当血清地高辛水平达到21.7纳克/毫升时，使用地高辛特异性Fab抗体片段结合游离血清地高辛。输注后立即检测，游离血清地高辛低于检测限，而总地高辛在5小时后达到峰值219纳克/毫升。心律失常并未完全消退，因此还放置了经静脉起搏器，但从未使用。抗体输注耐受性良好，男孩出院时身体健康。
