Riedel F, von Stockhausen H B
Eur J Clin Pharmacol. 1984;26(5):631-2. doi: 10.1007/BF00543498.
Accidental intoxication with tramadol of a 6-month old infant was followed by severe cerebral depression. Studies on serum, cerebrospinal fluid, and urine drug levels indicated complete penetration of the blood-cerebrospinal fluid barrier by tramadol.
一名6个月大的婴儿意外服用曲马多后出现严重的脑抑制。血清、脑脊液和尿液药物水平研究表明曲马多可完全穿透血脑屏障。