Friedel B
Arzneimittelforschung. 1978;28(1a):187-9.
1-(m-Methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol; Tramal) in oral doses of 150 mg/kg caused no essential changes in the EEG pattern in man. Only the alpha-rhythm of the occipital leads was more synchronized and the amplitude somewhat higher. beta-Waves increased slightly, but the delta-waves were not significantly changed. Tramadol induced no measurable alterations in the electronystagmographic recordings of quick voluntary eye movements or follow-up to-and-fro eye movements. In the optokinetic and postrotatory nystagmus, however, there was a moderate decrease in the total amplitude and maximal angular velocity of the slow nystagmic stage. The results of EEG and electronystagmographic investigations indicate that tramadol has a moderate relaxant (central depressant) effect.
1-（间甲氧基苯基）-2-（二甲基氨基甲基）-环己醇（曲马多；奇曼丁）口服剂量为150毫克/千克时，对人体脑电图模式无实质性改变。仅枕叶导联的α波更同步，振幅略有升高。β波略有增加，但δ波无明显变化。曲马多对快速随意眼球运动或来回眼球运动的眼震电图记录无明显改变。然而，在视动性眼震和旋转后眼震中，慢相眼震阶段的总振幅和最大角速度有适度降低。脑电图和眼震电图研究结果表明，曲马多具有适度的松弛（中枢抑制）作用。
