丙烯酰胺及其相关化合物对脑烯醇化酶的体外抑制作用及其构效关系。
Inhibition of brain enolases by acrylamide and its related compounds in vitro, and the structure-activity relationship.
作者信息
Tanii H, Hashimoto K
出版信息
Experientia. 1984 Sep 15;40(9):971-2. doi: 10.1007/BF01946464.
PMID:6468626
Abstract
Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones.
摘要
丙烯酰胺及其相关化合物在体外抑制脑烯醇化酶，与其神经毒性无关。抑制效力是化合物与苯丙氨酸结合常数的函数。神经毒性化合物中色氨酸的结合常数高于非神经毒性化合物。
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