Curstedt T, Casarett-Bruce M, Camner P
Exp Mol Pathol. 1984 Aug;41(1):26-34. doi: 10.1016/0014-4800(84)90004-2.
In rabbits exposed for 3 and 6 months to 1 mg/m3 of metallic nickel dust, the increase of pulmonary phospholipids was about 3 and 4 times, respectively. The corresponding increase of phospholipids in lung lavage was about 6 and 11 times, respectively. A detailed study of the phospholipid composition in lung lavage from the rabbits exposed for 3 months showed an increased amount of nonacidic phospholipids and a decreased amount of phosphatidylglycerols. Although most of the increase was due to the disaturated phosphatidylcholines, the relative increase was highest for the ether analogs of phosphatidylethanolamines. In the exposed rabbits the two ether analogs, 1-alk-1'-enyl-2-acyl- and 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamines, constituted 10.4 and 8.2%, respectively, of the phosphatidylethanolamine fraction. The corresponding values in the control rabbits were 5.2 and 0%, respectively. The occurrence of 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamines and the increase of 1-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoenthanolamines indicate that the biosynthetic synthetic pathway of ether lipids may be stimulated in the exposed rabbits. This is of interest since a high proportion of ether lipids is observed in many tumors and since some nickel compounds may give respiratory tumors.
在暴露于1毫克/立方米金属镍粉尘3个月和6个月的兔子中，肺磷脂的增加分别约为3倍和4倍。肺灌洗中磷脂的相应增加分别约为6倍和11倍。对暴露3个月的兔子肺灌洗中的磷脂组成进行的详细研究表明，非酸性磷脂的量增加，磷脂酰甘油的量减少。虽然大部分增加是由于二饱和磷脂酰胆碱，但磷脂酰乙醇胺的醚类似物的相对增加最高。在暴露的兔子中，两种醚类似物，1-烷-1'-烯基-2-酰基-和1-烷基-2-酰基-sn-甘油-3-磷酸乙醇胺，分别占磷脂酰乙醇胺组分的10.4%和8.2%。对照兔子中的相应值分别为5.2%和0%。1-烷基-2-酰基-sn-甘油-3-磷酸乙醇胺的出现以及1-烷-1'-烯基-2-酰基-sn-甘油-3-磷酸乙醇胺的增加表明，在暴露的兔子中，醚脂的生物合成途径可能受到刺激。这是有意义的，因为在许多肿瘤中观察到高比例的醚脂，并且因为一些镍化合物可能导致呼吸道肿瘤。
