[具有潜在抗肿瘤活性的化合物。II. 2-取代的3-(2-噻唑基)和3-[2-(1,3,4-噻二唑基)]-4-噻唑烷酮]

[Compounds with presumable antitumor activity. II. 2-Substituted 3-(2-thiazolyl) and 3-[2-(1,3,4,-thiadizolyl)]-4-thiazolidinones].

作者信息

Grasso S, Chimirri A, Monforte P, Fenech G

出版信息

Farmaco Sci. 1984 Jun;39(6):505-13.

Abstract

2-Substituted 3-(2-thiazolyl) and 3-[2-(1,3,4-thiadiazolyl)]-4-thiazolidinones were prepared and tested for their activity against the leukemic P 388 tumor system in mice. The thiadiazolyl derivatives are generally more active than the thiazolyl ones and some of them showed significant activity.

摘要

制备了2-取代的3-(2-噻唑基)和3-[2-(1,3,4-噻二唑基)]-4-噻唑烷酮，并对其在小鼠白血病P 388肿瘤系统中的活性进行了测试。噻二唑基衍生物通常比噻唑基衍生物更具活性，其中一些表现出显著活性。

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