[具有潜在抗肿瘤活性的化合物。IV. 1-芳基-N,N'-二-[2-(1,3,4-噻二唑基)]亚甲基二胺的合成及抗白血病活性]
[Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine].
作者信息
Grasso S, Chimirri A, Monforte P, Fenech G, Zappalà M
出版信息
Farmaco Sci. 1986 Sep;41(9):713-21.
PMID:3780959
Abstract
Some 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylendiamines were synthetized and tested against lymphocytic murine leukemia P 388. Compounds (I)-(III), (VIII)-(XII) and (XVIII)-(XIX) showed significant by prolongation the survival time of tumor-bearing mice (T/C% 129-194).
摘要
合成了一些1-芳基-N,N'-二-[2-(1,3,4-噻二唑基)]亚甲基二胺，并对其进行了抗小鼠淋巴细胞白血病P 388的测试。化合物（I）-（III）、（VIII）-（XII）和（XVIII）-（XIX）通过延长荷瘤小鼠的存活时间显示出显著效果（T/C%为129 - 194）。
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