大鼠视网膜中肾上腺素和苯乙醇胺N-甲基转移酶活性的鉴定。
Identification of epinephrine and phenylethanolamine N-methyltransferase activity in rat retina.
作者信息
Cohen J, Hadjiconstantinou M
出版信息
Fed Proc. 1984 Sep;43(12):2725-8.
PMID:6468670
Abstract
Epinephrine (E) and phenylethanolamine N-methyltransferase (PNMT) are endogenous to the rat retina. The retinal enzyme shows substrate specificity and inhibitor sensitivity similar to the PNMT of brain. The E system in the retina may be part of a functional adrenergic system, because amine metabolism of dopamine-containing amacrine cells is inhibited by alpha 2 agonists and stimulated by alpha 2 antagonists.
摘要
肾上腺素（E）和苯乙醇胺N-甲基转移酶（PNMT）在大鼠视网膜中内源性存在。视网膜中的这种酶表现出与脑内PNMT相似的底物特异性和抑制剂敏感性。视网膜中的E系统可能是功能性肾上腺素能系统的一部分，因为含多巴胺的无长突细胞的胺代谢受到α2激动剂的抑制，并受到α2拮抗剂的刺激。
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