大鼠视网膜苯乙醇胺-N-甲基转移酶活性的产后发育

Postnatal development of phenylethanolamine-N-methyltransferase activity of rat retina.

作者信息

Cohen J

机构信息

Department of Pharmacology, Graduate School of Arts & Sciences, Howard University, Washington, DC 20059.

出版信息

Neurosci Lett. 1987 Dec 16;83(1-2):138-42. doi: 10.1016/0304-3940(87)90230-8.

DOI:10.1016/0304-3940(87)90230-8

PMID:2894621

Abstract

The postnatal development of rat retinal phenylethanolamine-N-methyltransferase (PNMT) activity was measured by radiometric assay. Activity was detected on day 1 of life. Retinal PNMT activity of day 1 neonates approximated 10% that of the adult. There is an increase in enzyme activity before eye opening. By day 30, enzyme activity has peaked. The enzyme during this early period possesses the same substrate specificity and inhibitor sensitivity as that of the adult enzyme. PNMT activity is detected before tyrosine hydroxylase activity.

摘要

通过放射性测定法测量了大鼠视网膜苯乙醇胺 -N-甲基转移酶（PNMT）活性的出生后发育情况。在出生后第1天检测到了活性。出生后第1天新生儿的视网膜PNMT活性约为成年大鼠的10%。在睁眼之前酶活性有所增加。到第30天，酶活性达到峰值。在此早期阶段，该酶具有与成年酶相同的底物特异性和抑制剂敏感性。在酪氨酸羟化酶活性之前就检测到了PNMT活性。