阿托品对人胆囊收缩素诱导的胆囊收缩的抑制作用。

Inhibitory effect of atropine on cholecystokinin-induced gallbladder contraction in man.

作者信息

Gullo L, Bolondi L, Priori P, Casanova P, Labò G

出版信息

Digestion. 1984;29(4):209-13. doi: 10.1159/000199035.

DOI:10.1159/000199035

Abstract

We have studied the effect of atropine on cholecystokinin (CCK)-induced gallbladder contraction in 7 healthy volunteers by means of real-time ultrasonography. Two series of tests were carried out in random order and on separate days. In one series of tests, CCK alone was infused for 4 successive 15-min periods at sequentially increasing doses of 0.0021, 0.0042, 0.0084, and 0.0168 Ivy dog units (IDU) X kg-1 X min-1. In the other series of tests, an infusion of a low dose of atropine, 5 micrograms X kg-1 X h-1, was added to the hormone infusion. The smallest dose of CCK which significantly contracted the gallbladder was 0.0042 IDU X kg-1 X min-1. The highest dose of CCK infused, 0.0168 IDU X kg-1 X min-1, produced almost total contraction of the organ. In all subjects, the infusion of atropine completely blocked the gallbladder response to 0.0042 and 0.0084 IDU X kg-1 X min-1, and partially inhibited (by 52%) the response to the highest dose. In 2 subjects in whom a higher dose of atropine, 15 micrograms X kg-1 X h-1, was tested, gallbladder contraction was totally abolished, even when the largest dose of CCK was infused. Contrary to what is generally believed, the results indicate that the response of human gallbladder to CCK is largely dependent on cholinergic innervation.

摘要

我们通过实时超声检查研究了阿托品对7名健康志愿者胆囊收缩素（CCK）诱导的胆囊收缩的影响。两组测试以随机顺序在不同日期进行。在一组测试中，单独输注CCK，连续4个15分钟时段，依次增加剂量，分别为0.0021、0.0042、0.0084和0.0168 Ivy犬单位（IDU）×kg⁻¹×min⁻¹。在另一组测试中，在激素输注中加入低剂量阿托品输注，5微克×kg⁻¹×h⁻¹。能使胆囊显著收缩的最小CCK剂量为0.0042 IDU×kg⁻¹×min⁻¹。输注的最高CCK剂量，0.0168 IDU×kg⁻¹×min⁻¹，使该器官几乎完全收缩。在所有受试者中，阿托品输注完全阻断了胆囊对0.0042和0.0084 IDU×kg⁻¹×min⁻¹的反应，并部分抑制（52%）了对最高剂量的反应。在2名测试了更高剂量阿托品（15微克×kg⁻¹×h⁻¹）的受试者中，即使输注最大剂量的CCK，胆囊收缩也完全被消除。与普遍看法相反，结果表明人类胆囊对CCK的反应很大程度上依赖于胆碱能神经支配。